- In the Season 1 episode "Phantom Traveler," Sam and Dean investigate the disappearance of several people from a small town in Kentucky. They discover that the disappearances are being caused by a phantom that is haunting the town.
- In the Season 2 episode "Simon Said," Sam and Dean investigate a series of murders in a small town in Kentucky. They discover that the murders are being committed by a demon who is possessing the body of a young boy.
- In the Season 6 episode "Frontierland," Sam and Dean travel back in time to the 1800s to investigate the disappearance of a young woman in Kentucky. They discover that the woman is being held captive by a group of vampires.