Main Arch-Enemies:
* Reverse Flash (Eobard Thawne): Arguably Flash's greatest and most enduring nemesis, the Reverse Flash is a time-traveling supervillain obsessed with the Flash. He possesses similar abilities to Flash but with a twisted personality and desire to conquer time itself.
* Captain Cold (Leonard Snart): A master strategist and skilled weapon inventor, Captain Cold uses a cold gun to freeze his opponents and often leads the Rogues, a group of Flash's recurring villains.
* Heat Wave (Mick Rory): Captain Cold's partner in crime, Heat Wave possesses a heat gun and a pyromaniacal personality, often clashing with Flash's speed.
* Zoom (Hunter Zolomon): A supervillain with the power to manipulate time, Zoom is ruthless and willing to do anything to achieve his goals, even if it means causing immense pain and suffering.
* Grodd: A highly intelligent and powerful gorilla with telepathic abilities, Grodd is a recurring threat to Central City and a formidable opponent for Flash.
Other Notable Enemies:
* Mirror Master (Sam Scudder): A villain with the ability to create illusions and manipulate mirrors, Mirror Master is a master of misdirection and frequently causes chaos and mayhem in Central City.
* The Top (Roscoe Dillon): A master of speed and agility, The Top uses a spinning top as his weapon to create dizzying and disorienting effects.
* Weather Wizard (Mark Mardon): A powerful weather manipulator with a desire to control the elements and use them for his own evil purposes.
* Pied Piper (Hartley Rathaway): A brilliant musical genius with the ability to control sound waves, Pied Piper can manipulate people's minds and emotions with his music.
* Gorilla Grodd: A highly intelligent and powerful gorilla with telepathic abilities, Grodd is a recurring threat to Central City and a formidable opponent for Flash.
This is not an exhaustive list, as Flash has faced many other villains throughout his comic book history. However, these are some of his most well-known and recurring enemies.