- The Originals return to Mystic Falls and take over the search for the cure.
- Elena falls in love with Damon and they begin a romantic relationship.
- Stefan and Caroline also begin a romantic relationship.
- Klaus makes a deal with Tyler Lockwood to protect him from the Originals.
- Bonnie makes a deal with Abby Bennett Wilson to resurrect Jeremy.
- Katherine Pierce returns to Mystic Falls and causes trouble for everyone.
- The Originals are defeated and the cure is destroyed.
- Elena becomes a vampire.
- Stefan sacrifices himself to save Damon.