How are Johannes Gutenberg and William Shakespeare related?

There is no direct relationship between Johannes Gutenberg and William Shakespeare. Gutenberg lived from 1398 to 1468 and is recognized as the inventor of the printing press in Europe, while Shakespeare lived from 1564 to 1616 and is considered one of the greatest writers in the English language. Gutenberg's innovation in printing significantly affected the spread of information and played a crucial role in the Renaissance and Reformation, but it did not directly influence Shakespeare's life or work.