* Mary I (1516-1558): She later became Queen of England, known as "Bloody Mary" for her religious persecution of Protestants.
They also had several children who died in infancy:
* Henry, Duke of Cornwall (1511): Died shortly after birth.
* A daughter (1510): Died shortly after birth.
* A son (1514): Stillborn.
* A daughter (1518): Died shortly after birth.
It's worth noting that the lack of a male heir was a major factor in Henry's decision to divorce Catherine and marry Anne Boleyn, which led to the English Reformation.