However, some strong contenders for the title include:
* The Bible: The Bible has had a profound impact on American culture and history, and is likely the most widely read and influential book in the country.
* The Adventures of Huckleberry Finn: Mark Twain's classic novel is considered a cornerstone of American literature and has had a lasting impact on American culture.
* To Kill a Mockingbird: Harper Lee's Pulitzer Prize-winning novel is widely read and admired for its exploration of racial injustice and its enduring themes.
* The Catcher in the Rye: J.D. Salinger's novel has been a cultural touchstone for generations of American readers.
* The Great Gatsby: F. Scott Fitzgerald's novel is a classic of American literature that has captured the imagination of readers for nearly a century.
Ultimately, the most famous book in America is a matter of opinion and depends on individual perspectives and criteria.