Follow the conventions of the traditional novel. Just because a novel is "new" or "edgy", that's no reason to disregard time-honored concepts like a well-developed plot line, careful attention to consistent diction and compelling, realistic dialogue. A writer ignores these aspects at his/her peril, even for a "pop" novel.
Create accessible characters. If your novel is truly going to appeal to pop culture, the hook starts with the characters. Grow characters that have a "pop mindset;" straightforward, uncomplicated, and even sometimes glib characters without a lot of baggage. A city-dwelling, fast-moving lawyer is better for a pop novel than an eccentric professor of medieval studies. That's not to say a pop novel limits your ability to create: it just promotes a certain kind of characterization.
Generate a popular setting. Novels set in ancient Egypt or historical Jamestown will probably not lend themselves to a "pop" appeal. A really ground-breaking pop novel will bend conventions to introduce elements that are near and dear to the hearts of post-modern readers. Think Albert Camus for 2007.
Write active, not passive. Again, the pop novel does not oblige a writer to set rules, but guidelines on style can come in handy, preventing a novel from getting top-heavy, which might be okay in some esoteric genres, but not if a writer is going for popular appeal. Use flashy, concise sentences to reach out to readers. Keep the plot going, keep it action-driven, keep it relevant and real.
Consider adding graphics. One aspect of "pop literature" is the graphic novel, which has been gaining ground quickly over the last few years. Your Barnes and Noble shelves today have a widening section for graphic novels of all sorts. It was probably a predictable result of visual mass media and digital technology, but it's true in any case that graphic novels have their own kind of "pop" appeal, and even just including several illustrations can give a novel its own feeling of innovation.