Some of her most notable works include:
- Fiction:
- _The Song in the Stone_ (1928)
- _The Hollow_ (1931)
- _Wings Over Georgia_ (1934)
- _Death Over the Woods_ (1936)
- _The Blue Hills_ (1938)
- _That Which Was_ (1941)
- _The Bracelet of Stars_ (1943)
- _The Flower of Time_ (1945)
- _The Star-Spangled Banner_ (1946)
- _Carolina Caravan_ (1947)
- Non-Fiction:
- _How to Write and Sell Short Stories_ (1936)
- _How to Write and Sell Magazine Articles_ (1937)
- _The Colonel and Miss Ann: Personal Letters of Colonel and Mrs. William Dearing Howells, 1890-1897_ (1939)
- _Journal of a Pilgrimage to the Homes of William and Mary Howells_ (1940)
- Poetry:
- _Poems of the South_ (1932)
- _The Book of the Sonnet_ (1937)
- Children's Literature:
- _Billy and Blaze_ (1936)
- _Billy and Blaze and Bessie_ (1938)
- _Billy and Blaze Go Sailing_ (1940)
- _The Adventures of Chippy and the Chipmunk_ (1942)
- Plays:
- _Wings Over Georgia_ (1933)
- _How Can We Help?_ (1935)
- _The Land of Dreams_ (1937)
- Articles and Short Stories:
Ruth Nichols wrote extensively for newspapers and magazines, including _The Saturday Evening Post_, _Ladies' Home Journal_, _Collier's_, and _The New Yorker_. Her short stories and articles often appeared in anthologies and collections.
Awards: _The Song in the Stone_ won the Southern Writers' Award in 1928, and _Wings Over Georgia_ won the Georgia Writers' Association Award in 1935.
Nichols's work has been praised for its rich detail, emotional depth, and insights into the human condition. She is considered an important figure in Southern literature and American journalism.