* The Dispossessed (1974)
* The Orphan Master's Son (2002)
* The Brief Wondrous Life of Oscar Wao (2007)
* The Amazing Adventures of Kavalier & Clay (2010)
* I Am Cuba: Stories (2012)
* The Prague Cemetery (2012)
* The Story of My Teeth (2015)
* Mona Lisa Overdrive (2015)
* Patria (2018)
* The Wind-Up Bird Chronicle (1994)
Non-Fiction
* An Image of Africa: Racism in Conrad's "Heart of Darkness" (1971)
* Second Chance (1983)
* Chronicles of Latin America: A History (2006)
* The World According to Peanuts: A Book About Cartoons, Pop Culture, and Life (2011)
* Why Write? (2015)
* Conversations with Myself (2019)