* The Isenheim Altarpiece: This monumental altarpiece is considered one of the most powerful and influential works of Northern Renaissance art. It depicts scenes from the life of Christ, and is particularly noted for its intense emotionalism, vivid colors, and realistic depictions of suffering.
* His unique style: Grünewald developed a highly individual style, characterized by dramatic contrasts of light and dark, intense emotional expression, and a focus on the physicality of the human body.
* His influence on later artists: Grünewald's work had a profound influence on artists such as Albrecht Dürer, Lucas Cranach the Elder, and Hans Holbein the Younger.
While Grünewald is relatively unknown compared to some of his contemporaries, his work is considered to be some of the most powerful and moving art of the Renaissance.