Write the story. The story is the most important part of your comic, determining the backgrounds and characters you will need to make and use, and how scenes will be arranged. LEGO figurines have certain limitations, such as a restricted range of movement and limited facial expressions; take these into consideration when writing your story.
Build the background. Some cartoonists choose to create sets entirely out of LEGOs, while others use natural environments as backdrops in their stories. When building your own sets, take care to ensure that there are unobstructed views of the figurines from different camera angles.
Refer to your story to determine the figurines for each scene. Pose them so that their actions and dialogue correspond. Include props where necessary. Be aware of issues that affect the comic's readability; for example, because Western cultures read from left to right, arrange characters so that the first one to speak is on the far left in dialogue scenes.
Photograph the scene, choosing camera angles that emphasize each scene's action. Use wide, establishing shots to open each scene and closeups for dialogue. Experiment with lighting techniques to establish mood.
Assemble the comic. Upload the photographs to your computer and use a photo manipulation program such as Gimp (see Resources below). Copy images into a new file and arrange as desired. Add word balloons and dialogue. Save a copy of the finished comic as a .jpeg or .png file.
Publish the comic by uploading to an existing website or blog, or create an account on a free webcomic webhost, such as Webcomics Nation.