Good vs. Evil: The novel explores the classic theme of good versus evil, represented by Sherlock Holmes and the Hound. Holmes embodies the power of reason and deduction, while the Hound symbolizes the forces of darkness and superstition.
The Human Condition: The novel also delves into the human condition, particularly the themes of fear, guilt, and redemption. Sir Henry Baskerville is haunted by his family's curse, while Dr. Mortimer grapples with guilt over the death of Sir Charles Baskerville. Holmes, however, represents the triumph of human intellect over superstition and fear.