Turn on the helium tank by twisting the helium release handle to the left. You may hear a slight hissing sound emitting from the helium tank.
Place the opening of the first balloon over the emitting tube of the helium tank and push down. This releases the helium gas into the balloon.
Pull the helium balloon off of the emitting tube while pinching the opening of the balloon.
Keep one thumb, pointer and middle finger pinching down on the balloon, and use the other hand to pull the opening of the balloon, stretching it out.
Wrap the stretched out end of the balloon around the bottom of the thumb, then the two fingers. Instead of wrapping the opening around the thumb again, slide it up between the pointer and middle finger. This creates a knot. Pull the opening of the balloon up to tighten the knot so the helium stays inside.