Sketch your ideas in a storyboard format. Informally mock up the pages using the correct page proportions. With quick thumbnail sketches, create different layouts for the scene panels filling the page. Try various layouts that successfully create a logical flow for telling the story. Be creative without the story flow becoming contrary to the basic left to right, top to bottom logic. Try making larger panels for more dramatic scenes. Try using panels that run the full length or width of the page. All creative layout devices should bring something to the story.
Let it rest. Put the mock-up storyboard pages aside and stop thinking about it. Later, come back fresh and look at your pages as if you are a reader who knows only what you see on the page. The layout should be interesting and make logical sense to the reader.
Adjust your scene content to better tell the story. Adjust your scene layout to better tell the story. Keep in mind the dramatic impact of the visual elements you use. Strange and dramatic perspectives are a useful device but the visual content must be clear to the reader. A dramatic viewpoint only works if the reader gets it.
Keep it consistent. Whatever style of storytelling layout and sequencing you use on one page should follow throughout the book. If you bring an element in on one page, use some elements of that layout device on every page. This will help the reader stay in the flow of your graphic story.