In 2001, Barrymore co-founded the production company Flower Films. The company has produced several films, including Whip It (2009) and He's Just Not That Into You (2009).
In 2020, Barrymore began hosting her own talk show, The Drew Barrymore Show. The show has been a critical and commercial success, and has won several awards, including a Daytime Emmy Award for Outstanding Talk Show Entertainment.
In addition to her work in film and television, Barrymore has also written two books, Little Girl Lost (1990) and Wildflower (2015). She is also the co-founder of the beauty brand Flower Beauty.
Barrymore has been married three times. Her first husband was Jeremy Thomas, whom she married in 1994. They divorced in 1995. Her second husband was Tom Green, whom she married in 2001. They divorced in 2002. Her third husband is Will Kopelman, whom she married in 2012. They have two children together, a daughter named Olive and a son named Frankie. They divorced in 2016.