* Dwayne Johnson as Ray Gaines
* Carla Gugino as Emma Gaines
* Alexandra Daddario as Blake Gaines
* Ioan Gruffudd as Daniel Riddick
* Archie Panjabi as Serena Johnson
* Paul Giamatti as Dr. Lawrence Hayes
* Hugo Johnstone-Burt as Ollie
* Art Parkinson as Ben Taylor
* Kylie Minogue as Susan Riddick
* Will Yun Lee as Dr. Kim Park