* James Cromwell as General Jonathan Greener
* Jessica Pare as Lt. Colonel Alana Morales
* Sam Worthington as Lt. Colonel Jake Sully
* Zoe Saldana as Neytiri
* Sigourney Weaver as Dr. Grace Augustine
* Michelle Rodriguez as Trudy Chacón
* Giovanni Ribisi as Parker Selfridge
* Stephen Lang as Colonel Miles Quaritch
* CCH Pounder as Mo'at
* Joel David Moore as Norm Spellman
* Dileep Rao as Dr. Max Patel
* Laz Alonso as Tsu'tey