- David Duchovny as Fox Mulder
- Gillian Anderson as Dana Scully
- Mitch Pileggi as Walter Skinner
- William B. Davis as Cigarette Smoking Man
- Nicholas Lea as Alex Krycek
- Robert Patrick as John Doggett
- Annabeth Gish as Monica Reyes
- Chris Owens as Jeffrey Spender
- Laurie Holden as Marita Covarrubias
- Dean Haglund as Richard "Ringo" Langly
- Tom Braidwood as Melvin Frohike
- Bruce Harwood as John Fitzgerald Byers