* Michael Peña as Father Lozano
* Dougray Scott as Father Thomas
* Katie Holmes as Angie
* Djimon Hounsou as Father Imani
* Peter Andersson as Bishop McGuire
* Mark Kelly as Dr. Peters
* John Patrick Amedori as Jake
* Melissa Bolona as Sister Mary
* Evan Helmuth as Mark
* Tom Ardavany as Young Priest
While the movie features a large cast, these are the most prominent roles.