* Nicolas Cage as Sailor Ripley
* Laura Dern as Lula Pace Fortune
* Willem Dafoe as Bobby Peru
* Diane Ladd as Marietta Fortune
* Crispin Glover as Dell
* Harry Dean Stanton as John "Johnny" Farragut
* Grace Zabriskie as Sister Helen
* J.C. Quinn as The Sheriff
* Donizetti "Don" Swayze as Billy
* William Forsythe as Cigarette Burns
These are just the main players. There are many other supporting actors and actresses who played key roles in the movie.