* Anthony Hopkins as Hannibal Lecter
* Julianne Moore as Clarice Starling
* Gary Oldman as Mason Verger
* Ray Liotta as Paul Krendler
* Giancarlo Giannini as Inspector Rinaldo Pazzi
* Frankie Faison as Barney Matthews
* Philip Seymour Hoffman as Freddie Lounds
* Liv Tyler as Margot Verger
* Alessandro Nivola as Dr. Cordell
* Mark Bramhall as Agent Jim Pembry
This list includes the main actors, but there were many others in smaller roles.