* Louis CK as Louie, the show's main character, a gruff and often frustrated blue-collar worker.
* Pamela Adlon as Kim, Louie's wife, a loving but often exasperated woman.
* Fred Armisen as Eddie, Louie's best friend, a laid-back and sometimes clueless fellow.
* Megan Mullally as Lorna, Eddie's wife, a flamboyant and often over-the-top woman.
The show also featured recurring guest stars like:
* Jim Gaffigan as Peter, a friend of Louie's, often causing trouble.
* Stephen Root as Frank, Louie's father, an often absent but well-meaning man.
* Todd Barry as Bob, a friend of Louie's, known for his deadpan humor.
"Lucky Louie" was known for its unique blend of humor, grounded in reality, and for showcasing the struggles and triumphs of everyday people.