* Boris Karloff as Dr. Fu Manchu
* Jean Arthur as Helen Brent
* Lewis Stone as Nayland Smith
* Charles Starrett as Jack Raymond
* William B. Davidson as Petrie
* Arthur Hohl as the Chief of Police
* Dwight Frye as the Sikh
* Ethel Wales as Mrs. Petrie
* Elsa Peterson as Fah Lo Suee
* Myrtle Stedman as the Chief's Secretary
This film was a sequel to the 1929 silent film "The Man Who Laughs", also starring Boris Karloff as Dr. Fu Manchu.