* Charley Grapewin as Jeeter Lester
* Marjorie Rambeau as Ellie May Lester
* Gene Tierney as Ada Lester
* Lon Chaney Jr. as "Dude" Lester
* Elizabeth Patterson as "Plow-hand" (Mammy) Lester
* William Hopper as "Boss" Lester
* John Qualen as "Hadd" Lester
* Tom Tyler as "Junebug" Lester
* Anthony Quinn as "Pearl" Lester
* Dana Andrews as "Willard" Lester
* Paul Kelly as "Captain" Lester
* Ward Bond as "Sheriff"
The film was directed by John Ford and based on the play by Jack Kirkland, which in turn was adapted from the novel by Erskine Caldwell.