* Jackie Chan as "The Monkey King"
* Jet Li as "The Silent Monk"
* Michael Angarano as "Jason Tripitikas"
* Liu Yi Fei as "Golden Sparrow"
* Collin Chou as "Nie"
* Li Bingbing as "The Queen of the West"
* Max Zhang as "Lu Bu"
* James Fleet as "The Wizard"
* Thomas Jones as "The Black Panther"
* Richard Cetrone as "The One-Eyed Demon"
The film also features a number of supporting roles, including:
* Roger Yuan as "The Shadow"
* Mark Chao as "Prince Ning"
* Yu Rongguang as "The General"
* Jason Tobin as "Wong"
* David Wenham as "The Butcher"
* Wayne Cheng as "The General"
The film's cast is a mix of established action stars, up-and-coming actors, and veterans of Chinese cinema. The presence of Jackie Chan and Jet Li, two of the world's most renowned martial arts performers, was a major draw for audiences.