* David Essex and Shaun Cassidy (1978 West End production)
* Michael Crawford and Donny Osmond (1993 Broadway revival)
* Nathan Lane and Matthew Broderick (1997 London revival)
* Jason Alexander and Darren Criss (2013 Broadway revival)
In addition to these famous performers, many other talented actors have played the roles of Mickey and Eddie in productions of Blood Brothers around the world.