- Loss of sanity: The guilt and paranoia that came from his actions drove him to madness.
- Physical and mental health: His sleepless nights and constant anxiety negatively affected his health, causing sleepwalking and hallucinations.
- Relationships: His obsession with power alienated many of his allies, including his wife, Lady Macbeth.
- Loss of kingdom: Ultimately, his actions led to the downfall of his reign, with Macduff defeating him in battle.