Lady Macbeth's arguments appeal to Macbeth's ambition and desire for power. She highlights his "manhood" and questions his courage and masculinity if he fails to act. She also uses guilt and shame to pressure him, reminding him of his prior boasts about becoming king and suggesting that he is a coward if he does not follow through. Macbeth succumbs to Lady Macbeth's influence and eventually agrees to commit the crime, despite his initial reservations and fears.
As the story progresses, Macbeth becomes increasingly consumed by guilt and remorse after the murder of Duncan. He experiences psychological torment and hallucinations, which symbolize his troubled conscience and the weight of his crime. While Macbeth initially embraced Lady Macbeth's plan, he is unable to cope with the psychological and emotional consequences of his actions and ultimately falls apart, leading to his downfall and demise.