* Ethan Hawke as The Temporal Agent / John / F.F. "The Fizzle Bomber"
* Sarah Snook as The Woman / Jane / John's Mother
* Noah Taylor as Mr. Robertson
* Christopher Kirby as Barkeep
* Mackenzie Firgens as Barmaid
* Hugo Weaving as The Grandfather Paradox
Predestination is known for its unique time travel narrative and its clever use of a single actor (Ethan Hawke) to play multiple roles throughout the film.