Movie with Johnny Depp and charlize theron space?

There is no movie with Johnny Depp and Charlize Theron where they are both in space. They have never starred in a movie together, and there is no known project in the works that would feature them both in a space setting.

It's possible you're thinking of two different movies or mixing up the actors.

Can you provide more details about the movie you're thinking of? For example, what kind of genre was it? What was the plot? This might help identify the film.