* Chevy Chase as Irwin "Fletch" Fletcher
* Hal Holbrook as Dr. Bennington
* Julianne Moore as Amanda
* R. Lee Ermey as Colonel Hawkins
* Richard Libertini as Earl
* Dana Carvey as Larry
* Michael McKean as D.A. Stevens
* M. Emmet Walsh as Earl's Lawyer
* Barbara Babcock as Mrs. Bennington
* Ken Jenkins as Police Captain Hennessey
* Patricia Kalember as Barbara
* Clifton James as Judge Thornton
* David Paymer as Dr. Bartholomew
* John Larroquette as Narrator (voice)
While these are the most prominent cast members, there are many other supporting roles that fill out the cast.