* In the Marvel Cinematic Universe (MCU), Spider-Man's best friend is Ned Leeds, played by Jacob Batalon.
* In the Tobey Maguire Spider-Man trilogy, his best friend is Harry Osborn, played by James Franco.
* In the Andrew Garfield Spider-Man films, his best friend is Harry Osborn, played by Dane DeHaan.
So, the answer depends on which Spider-Man movie or universe you are asking about. Let me know if you have a specific Spider-Man film in mind, and I can tell you who plays his best friend!