* Dustin Hoffman as Shifu
* Angelina Jolie as Tigress
* Jackie Chan as Monkey
* Seth Rogen as Mantis
* Lucy Liu as Viper
* David Cross as Crane
* James Hong as Mr. Ping
* Randall Duk Kim as Grand Master Oogway
* Dennis Haysbert as Storming Ox
* Dan Fogler as Zeng
* Michael Clarke Duncan as Commander Vachir
* Ian McShane as Tai Lung