Classic Cinema:
* Boris Karloff famously played the monster in James Whale's 1931 film "Frankenstein." This is arguably the most iconic adaptation and the one most people think of when they hear the name.
* Colin Clive played Victor Frankenstein in the 1931 film.
Other Notable Films:
* Christopher Lee played the monster in "The Curse of Frankenstein" (1957).
* Robert De Niro played the creature in "Mary Shelley's Frankenstein" (1994).
* Benedict Cumberbatch played Victor Frankenstein in the 2015 film "Frankenstein."
Television:
* Patrick Troughton played the monster in the 1973-1974 BBC series "Frankenstein."
Stage:
* The role of the monster has been played by countless actors in stage adaptations over the years.
To give you the most accurate answer, please specify which adaptation of Frankenstein you're interested in.