In the context of friendship, the phrase suggests a deep sense of betrayal and disappointment when someone close to you, someone you trusted and considered a friend, turns against you. It highlights the pain of betrayal and the shattering of trust that comes when a friend becomes an enemy.
The phrase can also serve as a reminder of the importance of loyalty and faithfulness in friendship. It emphasizes that true friends should stand by each other through thick and thin, and that betraying a friend is one of the most hurtful things one can do.
The phrase "Et tu, Brute?" is a poignant reminder of the complexities and vulnerabilities of friendship, and the potential for even the closest relationships to turn sour.