* Darth Bane: The first Sith Lord after the Jedi-Sith War, he established the Rule of Two, which stated that there could only be two Sith Lords at a time: a master and an apprentice.
* Darth Zannah: Darth Bane's apprentice, she was the first female Sith Lord.
* Darth Cognus: Darth Zannah's apprentice, he was killed by Darth Bane in order to prevent him from becoming too powerful.
* Darth Millennial: Darth Cognus' apprentice, she was killed by Darth Zannah in order to prevent her from becoming too powerful.
* Darth Plagueis: Darth Sidious' master, he was a powerful Sith Lord who was able to manipulate the midi-chlorians to create life.
* Darth Sidious: The Sith Lord who orchestrated the Clone Wars and the Galactic Empire, he was the master of Darth Vader.
* Darth Vader: Darth Sidious' apprentice, he was the most powerful Sith Lord of his time, but he was ultimately redeemed by his son, Luke Skywalker.
* Darth Maul: A Zabrak Sith Lord who was trained by Darth Sidious, he was killed by Obi-Wan Kenobi in the film Star Wars: Episode I - The Phantom Menace.
* Count Dooku: A former Jedi Master who turned to the dark side and became Darth Sidious' apprentice, he was killed by Anakin Skywalker in the film Star Wars: Episode II - Attack of the Clones.
* General Grievous: A cyborg who was trained by Darth Sidious to lead the droid armies of the Separatists, he was killed by Obi-Wan Kenobi in the film Star Wars: Episode III - Revenge of the Sith.