* Kathryn Erbe (Detective Alexandra Eames): Erbe has continued to act in film and television, with notable roles in The Sinner (2017-present), The Good Fight (2017-2021), and Billions (2016-2023).
* Chris Noth (Detective Mike Logan): Noth has appeared in several films and television shows since Law & Order: Criminal Intent, including The Good Wife (2010-2016), The Good Fight (2017-2021), and Sex and the City (1998-2004).
* Jamey Sheridan (Captain James Deakins): Sheridan has continued to act in film and television, with notable roles in The Mentalist (2008-2015), Homefront (2013), and The Purge: Election Year (2016).
* Annabella Sciorra (Detective Serena Stevens): Sciorra has appeared in several films and television shows since Law & Order: Criminal Intent, including The Sopranos (1999-2007), What Doesn't Kill You (2008), and Luke Cage (2016-2018).
* Courtney B. Vance (Assistant District Attorney Ron Carver): Vance has continued to act in film and television, with notable roles in The People v. O. J. Simpson: American Crime Story (2016), Unforgettable (2011-2016), and The Closer (2005-2012).
* Eric Bogosian (Dr. Emil Skoda): Bogosian has continued to act in film and television, with notable roles in The Sopranos (1999-2007), Talk to Me (2007), and Under the Silver Lake (2018).
* Julianne Nicholson (Detective Megan Wheeler): Nicholson has continued to act in film and television, with notable roles in Masters of Sex (2013-2016), The Red Road (2014-2015), and The Outsider (2020).