Hugh Laurie (Dr. Gregory House):
- Continued acting in films and TV shows like "Veep," "Holmes and Watson," and the animated comedy-drama "Avenue 5."
Lisa Edelstein (Dr. Lisa Cuddy):
- Pursued more TV and film roles and appeared in shows like "Girlfriends' Guide to Divorce," "The Kominsky Method," and movies like "Love, Rosie."
Omar Epps (Dr. Eric Foreman):
- Appeared in TV shows including "Queen Sugar," "This Is Us," and feature films such as "Almost Christmas" and "Fatal Affair."
Robert Sean Leonard (Dr. James Wilson):
- Continued acting in theater, TV shows, and movies, including projects like "The Librarians," "Falling Skies," and the Netflix series "House of Cards."
Jesse Spencer (Dr. Robert Chase):
- Joined the long-running NBC drama "Chicago Fire" as Lieutenant Matthew Casey and became one of the series' lead characters.
Jennifer Morrison (Dr. Allison Cameron):
- Appeared in several TV shows, such as "Once Upon a Time," "Once Upon a Time in Wonderland," and more recently, "This Is Us."
Peter Jacobson (Dr. Chris Taub):
- Continued acting in TV shows and films, including recurring roles in series like "Ray Donovan" and "Colony."
Kal Penn (Dr. Lawrence Kutner):
- Left acting briefly to serve in the Obama administration as the Associate Director of the White House Office of Public Engagement. Afterward, returned to acting, appearing in shows like "Designated Survivor" and "Sunnyside" and directing projects.
Anne Dudek (Dr. Amber Volakis):
- Featured in various TV shows, including recurring roles in "Covert Affairs," "12 Monkeys," and "Perception."