- Homer Simpson (father)
- Marge Simpson (mother)
- Bart Simpson (son)
- Lisa Simpson (daughter)
- Maggie Simpson (infant daughter)
Supporting characters include:
- Abraham "Grampa" Simpson (granddad)
- Charles Montgomery "Monty" Burns (Mr. Burns) (boss)
- Waylon Smithers (Mr. Burns' assistant)
- Ned Flanders (neighbor)
- Edna Krabappel (Bart's teacher)
- Ralph Wiggum (Bart's classmate)
- Milhouse Van Houten (Bart's best friend)
- Nelson Muntz (Bart's bully)
- Janey Powell (Bart's childhood friend)
- Seymour Skinner (principal of Bart's school)
- Moe Szyslak (owner of Moe's Tavern)
- Lenny Leonard (Homer's coworker)
- Carl Carlson (Homer's coworker)
- Patty and Selma Bouvier (Marge's sisters)
- Jacqueline "Jackie" Bouvier (Marge's mother)
- Clancy Bouvier (Marge's father)