* Was fired from the show in 2011 after making numerous public statements criticizing the show and its creator, Chuck Lorre.
* Has since starred in a number of other television shows, including "Anger Management" and "The Goldbergs."
* In 2016, Sheen revealed that he is HIV-positive.
Jon Cryer
* Continued to star on "Two and a Half Men" until the show ended in 2015.
* Has since starred in a number of other television shows, including "The Ranch" and "NCIS: New Orleans."
* In 2020, Cryer released a memoir titled "So That Happened."
Angus T. Jones
* Played Jake Harper on "Two and a Half Men" from 2003 to 2015.
* In 2012, Jones made a controversial video in which he denounced the show and urged viewers to stop watching it.
* Jones has since left acting and is now studying at the University of Colorado Boulder.
Conchata Ferrell
* Played Berta on "Two and a Half Men" from 2003 to 2015.
* Has since starred in a number of other television shows, including "The Ranch" and "Mom."
* Ferrell died in 2020 at the age of 77.
Holland Taylor
* Played Evelyn Harper on "Two and a Half Men" from 2003 to 2015.
* Has since starred in a number of other television shows, including "The Practice" and "The L Word."
* Taylor is currently starring in the Netflix series "The Politician."