- Guilt and remorse over the murder of Duncan, Banquo, and Macduff's family.
- Fear of retribution and loss of power.
- Hallucinations and visions, such as the ghost of Banquo.
- Sleeplessness and insomnia.
- Paranoia and distrust of others.
- Mental breakdowns and loss of sanity.
Lady Macbeth
- Guilt and remorse over her role in Duncan's murder.
- Fear of discovery and punishment.
- Sleepwalking and insomnia.
- Hallucinations and visions, such as the bloodstain on her hand.
- Feelings of isolation and alienation.
- Mental breakdowns and loss of sanity.
- Suicidal thoughts and tendencies.