What was the biggest tragedy in life?

There is no such thing as "the biggest tragedy in life." Tragedy is a highly subjective experience, and different events can impact individuals differently. What might be considered a significant loss or source of tragedy to one person may have a totally different effect on another. It's possible for someone to consider several events or challenges within their lifetime equally impactful when it comes to their sense of loss or adversity. Additionally, personal perspectives and circumstances shape people's perceptions of major challenges and tragedies in life.