Television
* Frasier (1993-2004): Her most iconic role, playing Daphne Moon, the British nanny and confidante to Dr. Frasier Crane. This role earned her four Primetime Emmy Award nominations for Outstanding Supporting Actress in a Comedy Series.
* The Vicar of Dibley (1994-2007): She appeared in three episodes as a guest star.
* Hot in Cleveland (2010-2015): She played Joy Scroggs, one of the four main characters, a successful Hollywood producer who moves to Cleveland with her two best friends.
* The Good Place (2016-2020): She had a recurring role as the demon, Eleanor Shellstrop's mother.
* Murphy Brown (2018): She guest-starred as Corky Sherwood in this revival of the classic sitcom.
* The Resident (2018-present): She plays Dr. Kit Voss, a cardiothoracic surgeon.
* Sprung (2022-present): She plays Gloria, one of the main characters in this comedy series about a group of inmates who get released early due to the COVID-19 pandemic.
Film
* The Three Musketeers (1993): She played Constance Bonacieux.
* The Secret of NIMH (1982): She voiced the character of Mrs. Brisby.
* The Adventures of Rocky and Bullwinkle (2000): She played the role of the FBI Agent Karen Sympathy.
* Downsizing (2017): She played the role of Audrey.
* The Wilde Wedding (2018): She starred alongside Glenn Close.
* The Christmas Chronicles (2018): She voiced the character of Mrs. Claus.
This is not an exhaustive list, but it highlights some of her most well-known projects. Jane Leeves has consistently delivered memorable performances throughout her career and continues to be a popular and respected actress.