* Warner Oland as Charlie Chan
* Keye Luke as Lee Chan
* Pauline Frederick as Patricia Lane
* J. Carrol Naish as Michael "Mike" Roman
* Henry Brandon as Dr. Hugo Bauer
* Donald Meek as Dr. Samuel Lane
* Roscoe Karns as "Red" Harris
* Isabel Jewell as Helen "Honey" Harris
* Robert Barrat as Jack "The Weasel" Wilson
* Arthur Treacher as Sir Basil Halloway
The film was directed by Harry Lachman.