1. Greg's "cheese touch" prank: Greg tries to prank his older brother Rodrick by spreading the rumor that someone has the "cheese touch," which is a fictional contagious condition. This leads to a hilarious and chaotic situation at school.
2. Rodrick's band "Löded Diper": Rodrick's band, Löded Diper, gets a gig at the local middle school dance. Greg tries to use this to his advantage, hoping to be popular by association, but the band's performance is disastrous.
3. The school talent show: Greg tries to enter the school talent show to impress a girl he likes, but his performance is ruined when Rodrick sabotages him.
4. The "cheese touch" incident: The cheese touch prank backfires when Rodrick actually gets the cheese touch, leaving him distraught and facing a social stigma.
5. The family vacation: Greg and his family go on a camping trip, which turns out to be a nightmare for Greg. Rodrick makes life miserable for him, and their father's efforts to bond with his sons backfire spectacularly.