The cast of "The Talk of the Town" included:
* Cary Grant as Leopold Dilg
* Jean Arthur as Nora Shelley
* Ronald Colman as Professor Arthur 'Buzz' Bishop
While "A Letter from Home" is a notable part of the film, it doesn't have its own separate cast listing. The characters you see in that segment are the same ones played by Cary Grant, Jean Arthur, and Ronald Colman throughout the entire film.