Movies:
* I Shot Andy Warhol (1996) - This biographical drama is probably her most well-known role, where she plays Valerie Solanas, the woman who shot Andy Warhol.
* High Fidelity (2000) - She plays a record store employee alongside John Cusack in this romantic comedy.
* Lost in Translation (2003) - She has a small but memorable role as a young, aspiring actress in this Sofia Coppola film.
* The Hottest State (2006) - This indie romantic comedy features her as the lead female character.
* The Last Time I Saw Richard (2014) - She stars in this mystery film.
* The Wannabe (2015) - She plays the lead role in this independent crime film.
* The Vanishing of Sidney Hall (2017) - This mystery thriller features Natasha as a supporting character.
* The Woman in the Window (2021) - She appears in this psychological thriller starring Amy Adams.
Television:
* The Adventures of Brisco County, Jr. (1993-1994) - She played the role of "The Bird" in this western series.
* Party of Five (1994-2000) - She played the role of "Sarah Reeves" in this critically acclaimed teen drama.
* Walker, Texas Ranger (1993-2001) - She appeared in an episode of this long-running western series.
* Sex and the City (2001) - She guest starred in this popular HBO series.
* CSI: Miami (2002) - She appeared in an episode of this crime drama.
* The Shield (2002-2008) - She had a recurring role in this FX series.
* Law & Order: Special Victims Unit (2003) - She appeared in an episode of this long-running crime drama.
* House M.D. (2005) - She appeared in an episode of this medical drama.
* Grey's Anatomy (2006) - She appeared in an episode of this long-running medical drama.
* The L Word (2004-2009) - She had a recurring role in this Showtime series.
* Shameless (2011-2021) - She appeared in several episodes of this Showtime comedy-drama series.
* The Mindy Project (2012-2017) - She appeared in an episode of this comedy series.
* Insatiable (2018) - She appeared in an episode of this Netflix comedy-drama series.
This list is not exhaustive, but it includes some of her most notable and significant projects in film and television.