Main Characters
* Jamie Buchman: Played by Paul Reiser, Jamie is a documentary filmmaker and the show's narrator. He is intelligent, witty, and often neurotic.
* Frannie Buchman: Played by Helen Hunt, Frannie is a psychologist and Jamie's wife. She is warm, compassionate, and often more grounded than Jamie.
* Paul Buchman: Played by Richard Kind, Paul is Jamie's older brother, who often butts heads with Jamie. He is a self-absorbed and sarcastic character who is married to Lisa.
* Lisa Buchman: Played by Anne Ramsay, Lisa is Paul's wife, who is fiercely loyal and supportive of her husband, even when he makes questionable decisions.
* Ursula: Played by Bebe Neuwirth (seasons 1-6, guest star in season 7), Ursula is Frannie's eccentric and quirky best friend.
* Murray Buchman: Played by John Pankow, Murray is Jamie and Paul's father. He is a retired social worker who provides sage advice to his family.
* Sylvia Buchman: Played by Valerie Harper (season 1-4), Sylvia is Jamie and Paul's mother. She is a strong-willed and outspoken woman.
Recurring Characters
* The Mailman: Played by John Pankow, the mailman is a recurring character who interacts with Jamie and Frannie.
* The Doorman: Played by David Lloyd George, the doorman of their apartment building is another recurring character they frequently encounter.
* The Therapist: Played by Michael Richards, the therapist is a recurring character who Frannie seeks counsel from.
* The Neighbors: Played by various actors, the neighbors in their building are a source of constant amusement and occasional drama.
This list includes the most prominent characters from the show, but *Mad About You* featured many other memorable and recurring characters over its seven seasons.