Here's a breakdown:
* Charlie Sheen and the rest of the cast: Sheen's well-documented personal struggles and erratic behavior led to a highly publicized falling out with the cast and crew. His departure from the show in 2011 was very controversial, and he publicly criticized the producers and his former co-stars.
* Jon Cryer and Ashton Kutcher: Cryer and Kutcher had a generally positive working relationship, though some reports suggest a degree of tension during their time working together.
* Angus T. Jones and the rest of the cast: Jones, who played Jake Harper, publicly denounced the show in 2012 due to his religious beliefs, which led to a reduced role in the final seasons.
Overall, the cast's relationship was marked by significant discord, particularly in the later seasons. While Cryer and Kutcher seem to have maintained a professional relationship, Sheen's actions and the overall negativity surrounding his departure have likely impacted their dynamic.
It's important to note that these are based on reports and public statements, and the actual nature of their relationships may be more nuanced than what's publicly known.