Guilt: Macbeth's guilt over the murder of Duncan begins to consume him. He has nightmares, hallucinations, and becomes increasingly paranoid.
Isolation: Macbeth becomes increasingly isolated from his wife, his friends, and his subjects. He is no longer the popular and beloved general that he once was.
Tragic Flaw: Macbeth's tragic flaw is his inability to control his ambition and his guilt. These two forces ultimately lead to his downfall.
Noble Qualities: Despite his flaws, Macbeth is still a noble character. He is a brave and loyal warrior, and he is deeply in love with his wife. These noble qualities make his downfall all the more tragic.